Wykorzystanie inhibitorów PDE4 w leczeniu depresji

Autorzy

Błażej Pilarski
Studenckie Koło Naukowe przy Katedrze i Zakładzie Biofizyki im. prof. Zbigniewa Religi, Wydział Nauk Medycznych w Katowicach, Śląski, Uniwersytet Medyczny w Zabrzu
Magdalena Stencel
Julia Kuca
Bartosz Bula

Słowa kluczowe:

depresja, inhibitory PDE4, rolipram

Streszczenie

Depresja jest jedną z najczęstszych chorób psychicznych. Zostaje w niej zaburzona praca ośrodkowego układu nerwowego. Inhibitory PDE4 są lekami wpływającymi na wzrost stężenia cAMP, dlatego mogą potencjalnie być zastosowane jako leki przeciwdepresyjne. Badania przeprowadzone na modelach zwierzęcych dają obiecujące wyniki w zakresie możliwości zastosowania tych leków w terapii depresji, również kliniczne badania wykazały porównywalną skuteczność tych leków ze standardowymi lekami przeciwdepresyjnymi. Potrzeba jednak kolejnych badań, w szczególności z zastosowaniem nowych związków, aby możliwe było wykorzystanie tych leków w praktyce klinicznej.  Celem niniejszego rozdziału jest omówienie aspektów związanych z wykorzystaniem inhibitorów PDE4 w leczeniu depresji. W tym celu przeanalizowano związaną z tematem literaturę dostępną w bazach medycznych takich jak: PubMed, Google Scholar, Scopus.

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