Wykorzystanie inhibitorów PDE4 w leczeniu depresji
Słowa kluczowe:
depresja, inhibitory PDE4, rolipramStreszczenie
Depresja jest jedną z najczęstszych chorób psychicznych. Zostaje w niej zaburzona praca ośrodkowego układu nerwowego. Inhibitory PDE4 są lekami wpływającymi na wzrost stężenia cAMP, dlatego mogą potencjalnie być zastosowane jako leki przeciwdepresyjne. Badania przeprowadzone na modelach zwierzęcych dają obiecujące wyniki w zakresie możliwości zastosowania tych leków w terapii depresji, również kliniczne badania wykazały porównywalną skuteczność tych leków ze standardowymi lekami przeciwdepresyjnymi. Potrzeba jednak kolejnych badań, w szczególności z zastosowaniem nowych związków, aby możliwe było wykorzystanie tych leków w praktyce klinicznej. Celem niniejszego rozdziału jest omówienie aspektów związanych z wykorzystaniem inhibitorów PDE4 w leczeniu depresji. W tym celu przeanalizowano związaną z tematem literaturę dostępną w bazach medycznych takich jak: PubMed, Google Scholar, Scopus.
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