Egzosomy jako bezkomórkowa metoda w promowaniu gojenia ran skóry
Słowa kluczowe:
egzosomy, mezenchymalne komórki macierzyste, rany skóry, regeneracja skóryStreszczenie
Leczenie ran to nieodzowna część medycyny, z której problematyką borykają się klinicyści, badacze naukowi oraz pacjenci cierpiący z tej przyczyny zarówno fizycznie jak i finansowo. Na przestrzeni ostatnich lat pojawiły się dowody, że mezenchymalne komórki macierzyste (MSC) mogą pomóc zaradzić temu problemowi. Jednakże bezpośrednie zastosowanie MSC nadal napotyka wiele wyzwań i trudności, dlatego badacze zwrócili swoją uwagę na egzosomy pochodzące od MSC (MSC-EXOS). MSC-EXOS wykazują bliźniacze właściwości co MSC, dlatego też ich wykorzystanie może być obiecującą alternatywą jako bezkomórkowa terapia w leczeniu ran skórnych. Ta praca ma na celu przedstawienie dowodów naukowych potwierdzających zdolności MSC-EXOS do korzystnej regulacji procesów gojenia ran skóry poprzez m.in. promowanie angiogenezy i proliferacji fibroblastów, niwelowanie stanów zapalnych oraz redukcję bliznowacenia ran.
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Opublikowane
6 lipca 2024
Prawa autorskie (c) 2024 Paweł Krupa; Sebastian Kościjański, Karolina Zięba, Jakub Kmieć, Zuzanna Złotnicka
Licencja
Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Użycie niekomercyjne – Bez utworów zależnych 4.0 Międzynarodowe.
