Nanoceria w biomedycynie

Autorzy

Karolina Gancarczyk
Studenckie Koło Naukowe przy Katedrze i Zakładzie Biofizyki im. prof. Zbigniewa Religi, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
Daria Kaczor
Studenckie Koło Naukowe przy Katedrze i Zakładzie Biofizyki im. prof. Zbigniewa Religi, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
Daria Rost
Studenckie Koło Naukowe przy Katedrze i Zakładzie Biofizyki im. prof. Zbigniewa Religi, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach

Słowa kluczowe:

nanoceria, antyoksydacyjne, CeO2, regeneracja, redoks

Streszczenie

Nanoceria, dzięki swoim unikalnym właściwościom przeciwutleniającym, wykazuje potencjał w ochronie komórek przed stresem oksydacyjnym, który jest kluczowym czynnikiem w patogenezie wielu chorób, w tym chorób neurodegeneracyjnych, kardiologicznych i cukrzycy. Badania wykazały również, że nanoceria może promować regenerację tkanek, np. w terapiach regeneracyjnych skóry i kości. Ponadto, zdolność nanocerii do precyzyjnego docierania do określonych miejsc w organizmie czyni ją obiecującym narzędziem w celowanym leczeniu i obrazowaniu medycznym. Nanoceria oferuje szerokie spektrum możliwości w biomedycynie, jednakże wymaga dalszych badań dotyczących jej biodystrybucji, metabolizmu, długoterminowego wpływu na organizm oraz potencjalnych efektów toksycznych. Przyszłe badania powinny również skupić się na rozwoju innowacyjnych strategii bioinżynieryjnych, które pozwolą na zwiększenie celowości działania i redukcję efektów ubocznych, co umożliwi przejście od eksperymentalnych badań laboratoryjnych do zastosowań klinicznych

Rozdziały

  • Nanoceria w biomedycynie

Bibliografia

Sadidi H, Hooshmand S, Ahmadabadi A, et al. Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering. Molecules. 2020;25(19):4559. Published 2020 Oct 6. doi:10.3390/molecules25194559

Nelson BC, Johnson ME, Walker ML, Riley KR, Sims CM. Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine. Antioxidants (Basel). 2016;5(2):15. Published 2016 May 17. doi:10.3390/antiox5020015

Khan SB, Faisal M, Rahman MM, Jamal A. Exploration of CeO₂ nanoparticles as a chemi-sensor and photo-catalyst for environmental applications. Sci Total Environ. 2011;409(15):2987-2992. doi:10.1016/j.scitotenv.2011.04.019

Xia C, Jin X, Garalleh HA, et al. Optimistic and possible contribution of nanomaterial on biomedical applications: A review. Environ Res. 2023;218:114921. doi:10.1016/j.envres.2022.114921

Van Hoecke K, Quik JT, Mankiewicz-Boczek J, et al. Fate and effects of CeO2 nanoparticles in aquatic ecotoxicity tests. Environ Sci Technol. 2009;43(12):4537-4546. doi:10.1021/es9002444

Sarkar S, Zhang L, Subramaniam P, et al. Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells. PLoS One. 2014;9(5):e97304. Published 2014 May 13. doi:10.1371/journal.pone.0097304

Hossain MK, Toki GFI, Samajdar DP, et al. Deep Insights into the Coupled Optoelectronic and Photovoltaic Analysis of Lead-Free CsSnI3 Perovskite-Based Solar Cell Using DFT Calculations and SCAPS-1D Simulations. ACS Omega. 2023;8(25):22466-22485. Published 2023 Jun 14. doi:10.1021/acsomega.3c00306

Feng N, Liu Y, Dai X, Wang Y, Guo Q, Li Q. Advanced applications of cerium oxide based nanozymes in cancer. RSC Adv. 2022;12(3):1486-1493. Published 2022 Jan 10. doi:10.1039/d1ra05407d

Bi X, Zeng C, Westerhoff P. Adsorption of Arsenic Ions Transforms Surface Reactivity of Engineered Cerium Oxide Nanoparticles. Environ Sci Technol. 2020;54(15):9437-9444. doi:10.1021/acs.est.0c02781

de Souza TAJ, Rocha TL, Franchi LP. Detection of DNA Damage Induced by Cerium Dioxide Nanoparticles: From Models to Molecular Mechanism Activated. Adv Exp Med Biol. 2018;1048:215-226. doi:10.1007/978-3-319-72041-8_13

Chen BH, Stephen Inbaraj B. Various physicochemical and surface properties controlling the bioactivity of cerium oxide nanoparticles. Crit Rev Biotechnol. 2018;38(7):1003-1024. doi:10.1080/07388551.2018.1426555

Charbgoo F, Ahmad MB, Darroudi M. Cerium oxide nanoparticles: green synthesis and biological applications. Int J Nanomedicine. 2017;12:1401-1413. Published 2017 Feb 20. doi:10.2147/IJN.S124855

Adamson AW. Advanced Inorganic Chemistry. by F. A. Cotton and G. Wilkinson. Inorganic Chemistry. 1963;2(3):665. doi:10.1021/ic50007a079

Singh S. Cerium oxide based nanozymes: Redox phenomenon at biointerfaces. Biointerphases. 2016;11(4). doi:10.1116/1.4966535

Deshpande SB, Patil S, Kuchibhatla SVNT, Seal S. Size dependency variation in lattice parameter and valency states in nanocrystalline cerium oxide. Applied Physics Letters. 2005;87(13):133113. doi:10.1063/1.2061873

Han SI, Lee SW, Cho MG, et al. Epitaxially Strained CeO2 /Mn3 O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection. Adv Mater. 2020;32(31):e2001566. doi:10.1002/adma.202001566

Saifi MA, Seal S, Godugu C. Nanoceria, the versatile nanoparticles: Promising biomedical applications. J Control Release. 2021;338:164-189. doi:10.1016/j.jconrel.2021.08.033

Lu M, Zhang Y, Wang Y, Jiang M, Yao X. Insight into Several Factors that Affect the Conversion between Antioxidant and Oxidant Activities of Nanoceria. ACS Appl Mater Interfaces. 2016;8(36):23580-23590. doi:10.1021/acsami.6b08219

Thakur N, Manna P, Das J. Synthesis and biomedical applications of nanoceria, a redox active nanoparticle. J Nanobiotechnology. 2019;17(1):84. Published 2019 Jul 10. doi:10.1186/s12951-019-0516-9

Chen M, Zhou X, Xiong C, et al. Facet Engineering of Nanoceria for Enzyme-Mimetic Catalysis. ACS Appl Mater Interfaces. 2022;14(19):21989-21995. doi:10.1021/acsami.2c04320

Zhang J, Wang J, Liao J, Lin Y, Zheng C, Liu J. In Situ Fabrication of Nanoceria with Oxidase-like Activity at Neutral pH: Mechanism and Boosted Bio-Nanozyme Cascades. ACS Appl Mater Interfaces. 2021;13(42):50236-50245. doi:10.1021/acsami.1c14831

Mu J, Zhao X, Li J, Yang EC, Zhao XJ. Coral-like CeO2/NiO nanocomposites with efficient enzyme-mimetic activity for biosensing application. Mater Sci Eng C Mater Biol Appl. 2017;74:434-442. doi:10.1016/j.msec.2016.12.037

Korsvik C, Patil S, Seal S, Self WT. Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem Commun (Camb). 2007;(10):1056-1058. doi:10.1039/b615134e

Heckert EG, Karakoti AS, Seal S, Self WT. The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials. 2008;29(18):2705-2709. doi:10.1016/j.biomaterials.2008.03.014

Baldim V , Bedioui F , Mignet N , Margaill I , Berret JF . The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce3+ surface area concentration. Nanoscale. 2018;10(15):6971-6980. doi:10.1039/c8nr00325d

Bhagat S, Srikanth Vallabani NV, Shutthanandan V, Bowden M, Karakoti AS, Singh S. Gold core/ceria shell-based redox active nanozyme mimicking the biological multienzyme complex phenomenon. J Colloid Interface Sci. 2018;513:831-842. doi:10.1016/j.jcis.2017.11.064

Xu F, Lu Q, Huang PJ, Liu J. Nanoceria as a DNase I mimicking nanozyme. Chem Commun (Camb). 2019;55(88):13215-13218. doi:10.1039/c9cc06782e

Farias IAP, Dos Santos CCL, Sampaio FC. Antimicrobial Activity of Cerium Oxide Nanoparticles on Opportunistic Microorganisms: A Systematic Review. Biomed Res Int. 2018;2018:1923606. Published 2018 Jan 23. doi:10.1155/2018/1923606

Nefedova A, Rausalu K, Zusinaite E, et al. Antiviral efficacy of cerium oxide nanoparticles. Sci Rep. 2022;12(1):18746. Published 2022 Nov 5. doi:10.1038/s41598-022-23465-6

Zholobak NM, Mironenko AP, Shcherbakov AB, et al. Cerium dioxide nanoparticles increase immunogenicity of the influenza vaccine. Antiviral Res. 2016;127:1-9. doi:10.1016/j.antiviral.2015.12.013

Jan H, Khan MA, Usman H, et al. The Aquilegia pubiflora (Himalayan columbine) mediated synthesis of nanoceria for diverse biomedical applications. RSC Adv. 2020;10(33):19219-19231. Published 2020 May 20. doi:10.1039/d0ra01971b

Mohamed HEA, Afridi S, Khalil AT, et al. Promising antiviral, antimicrobial and therapeutic properties of green nanoceria. Nanomedicine (Lond). 2020;15(5):467-488. doi:10.2217/nnm-2019-0368

Yokel RA, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee FR. The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity. Environ Sci Nano. 2014;1(5):406-428. doi:10.1039/C4EN00039K

Liman R, Acikbas Y, Ciğerci İH. Cytotoxicity and genotoxicity of cerium oxide micro and nanoparticles by Allium and Comet tests. Ecotoxicol Environ Saf. 2019;168:408-414. doi:10.1016/j.ecoenv.2018.10.088

Fernández-Varo G, Perramón M, Carvajal S, et al. Bespoken Nanoceria: An Effective Treatment in Experimental Hepatocellular Carcinoma. Hepatology. 2020;72(4):1267-1282. doi:10.1002/hep.31139

Chaudhury K, Babu K N, Singh AK, Das S, Kumar A, Seal S. Mitigation of endometriosis using regenerative cerium oxide nanoparticles. Nanomedicine. 2013;9(3):439-448. doi:10.1016/j.nano.2012.08.001

Hosseinmardi M, Siadat F, Sharafi M, Roodbari NH, Hezavehei M. Protective Effect of Cerium Oxide Nanoparticles on Human Sperm Function During Cryopreservation. Biopreserv Biobank. 2022;20(1):24-30. doi:10.1089/bio.2021.0020

Kumari P, Saifi MA, Khurana A, Godugu C. Cardioprotective effects of nanoceria in a murine model of cardiac remodeling. J Trace Elem Med Biol. 2018;50:198-208. doi:10.1016/j.jtemb.2018.07.011

Hosseini M, Mozafari M. Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering. Materials (Basel). 2020;13(14):3072. Published 2020 Jul 9. doi:10.3390/ma13143072

Liu D, Lu G, Shi B, et al. ROS-Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration. Adv Healthc Mater. 2023;12(18):e2300123. doi:10.1002/adhm.202300123

Yang W, Zhang M, He J, Gong M, Sun J, Yang X. Central nervous system injury meets nanoceria: opportunities and challenges. Regen Biomater. 2022;9:rbac037. Published 2022 Jun 2. doi:10.1093/rb/rbac037

Cai X, McGinnis JF. Nanoceria: a Potential Therapeutic for Dry AMD. Adv Exp Med Biol. 2016;854:111-118. doi:10.1007/978-3-319-17121-0_16

Alrobaian M. Pegylated nanoceria: A versatile nanomaterial for noninvasive treatment of retinal diseases. Saudi Pharm J. 2023;31(10):101761. doi:10.1016/j.jsps.2023.101761

Tang JLY, Moonshi SS, Ta HT. Nanoceria: an innovative strategy for cancer treatment. Cell Mol Life Sci. 2023;80(2):46. Published 2023 Jan 19. doi:10.1007/s00018-023-04694-y

Wu G, Zhang Z, Chen X, Yu Q, Ma X, Liu L. Chemosensitization effect of cerium oxide nanosheets by suppressing drug detoxification and efflux. Ecotoxicol Environ Saf. 2019;167:301-308. doi:10.1016/j.ecoenv.2018.10.013

Liu H, Ji M, Bi Y, et al. Integration of MyD88 inhibitor into mesoporous cerium oxide nanozymes-based targeted delivery platform for enhancing treatment of ulcerative colitis. J Control Release. 2023;361:493-509. doi:10.1016/j.jconrel.2023.08.015

Vafaei-Pour Z, Shokrzadeh M, Jahani M, Shaki F. Embryo-Protective Effects of Cerium Oxide Nanoparticles against Gestational Diabetes in Mice. Iran J Pharm Res. 2018;17(3):964-975.

Xu H, Li S, Ma X, et al. Cerium oxide nanoparticles in diabetic foot ulcer management: Advances, limitations, and future directions. Colloids Surf B Biointerfaces. 2023;231:113535. doi:10.1016/j.colsurfb.2023.113535

Casals G, Perramón M, Casals E, et al. Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases. Antioxidants (Basel). 2021;10(5):660. Published 2021 Apr 24. doi:10.3390/antiox10050660

Zhang X, Hu J, Becker KV, et al. Antioxidant and C5a-blocking strategy for hepatic ischemia-reperfusion injury repair. J Nanobiotechnology. 2021;19(1):107. Published 2021 Apr 15. doi:10.1186/s12951-021-00858-9

Ni D, Wei H, Chen W, et al. Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection. Adv Mater. 2019;31(40):e1902956. doi:10.1002/adma.201902956

Dowding JM, Song W, Bossy K, et al. Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death. Cell Death Differ. 2014;21(10):1622-1632. doi:10.1038/cdd.2014.72

Sadowska-Bartosz I, Bartosz G. Redox nanoparticles: synthesis, properties and perspectives of use for treatment of neurodegenerative diseases. J Nanobiotechnology. 2018;16(1):87. Published 2018 Nov 3. doi:10.1186/s12951-018-0412-8

Yan S, Gao Z, Ding J, et al. Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome. J Nanobiotechnology. 2023;21(1):412. Published 2023 Nov 7. doi:10.1186/s12951-023-02182-w

García A, Cámara JA, Boullosa AM, et al. Nanoceria as Safe Contrast Agents for X-ray CT Imaging. Nanomaterials (Basel). 2023;13(15):2208. Published 2023 Jul 29. doi:10.3390/nano13152208

Ali Al Saidi AK, Ghazanfari A, Baek A, et al. Ultrasmall cerium oxide nanoparticles as highly sensitive X-ray contrast agents and their antioxidant effect. RSC Adv. 2024;14(6):3647-3658. Published 2024 Jan 23. doi:10.1039/d3ra08372a

Cao Y, Cheng K, Yang M, et al. Orally administration of cerium oxide nanozyme for computed tomography imaging and anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease. J Nanobiotechnology. 2023;21(1):21. Published 2023 Jan 19. doi:10.1186/s12951-023-01770-0

Opublikowane

6 lipca 2024