Skuteczność semaglutydu w leczeniu nadwagi i otyłości

Autorzy

Martyna Żurek
Studenckie Koło Naukowe im. Zbigniewa Religii, Katedra i Zakład Biofizyki, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
Zofia Graca
Aleksandra Skowronek

Streszczenie

Nadwaga i otyłość to globalny problem zdrowotny, stanowiący główny czynnik ryzyka schorzeń takich jak: cukrzyca, choroby sercowo-naczyniowe, choroby układu mięśniowo-szkieletowego i niektórych nowotworów. Semaglutyd to nowy lek zatwierdzony przez Agencję Żywności i Leków w celu leczenia nadwagi i otyłości. To analog ludzkiego glukagonopodobnego peptydu-1 (GLP-1). Reguluje wydzielanie insuliny i glukagonu, poprawia glikemię oraz hamuje apetyt i przyjmowanie pokarmu. Zaobserwowano, że dodatkowo wywiera korzystny wpływ na organizm, wykraczający poza redukcję masy ciała. W publikacji przedstawiono różnorodne artykuły wielokierunkowo omawiające skuteczność semaglutydu w leczeniu otyłości. Przeanalizowano dawkowanie, drogę podania, stosowanie u osób bez zaburzeń glikemii, łączenie farmakoterapii ze zmianą stylu życia, trwałość efektu terapii, działania niepożądane i badania porównujące efekty z innymi substancjami odchudzającymi. Przytoczone publikacje wykazały, że semaglutyd jest skuteczny i bezpieczny w leczeniu otyłości. To przełomowy lek, który stanowi szansę dla dużego odsetka społeczeństwa, które zmaga się z otyłością i jej konsekwencjami.

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7 czerwca 2023