Eradykacja Helicobacter pylori — skuteczność, oporność i przyszłość terapii
Słowa kluczowe:
helicobacter pylori, choroba wrzodowa, rak żołądka, antybiotykoopornośćStreszczenie
Zakażenie Helicobacter pylori jest najczęstszą przewlekłą infekcją na świecie oraz jednym z najistotniejszych czynników ryzyka gruczolakoraka żołądka i chłoniaka MALT żołądka. Z tego powodu liczba wykonywanych badań przesiewowych ciągle wzrasta, natomiast rosnąca oporność na środki przeciwdrobnoustrojowe, w tym antybiotyki, uniemożliwia optymalną terapię, a rosnąca antybiotykooporność jest zagrożeniem dla ludzkiego zdrowia. Te czynniki nakazują wdrożenie nowych wytycznych leczenia. Celem pracy jest przedstawienie globalnej skali tego wyzwania, różnorodnych powikłań związanych z zakażeniem H. pylori, takimi jak choroba wrzodowa, rak żołądka czy chłoniak MALT, ale przede wszystkim problematycznych aspektów obecnych strategii leczenia oraz przedstawienie najnowszych schematów eradykacji H. pylori.
Słowa kluczowe: helicobacter pylori, choroba wrzodowa, rak żołądka, antybiotykooporność
Bibliografia
Alipour M. Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer. Journal of Gastrointestinal Cancer. 2020;52(1).
Alkhaldi NK, Alghamdi WK, Alharbi MH, Almutairi AS, Alghamdi FT. The Association Between Oral Helicobacter pylori and Gastric Complications: A Comprehensive Review. Cureus. 2022;14(5):e24703.
Clarke E. Helicobacter pylori: Kompleksowy przegląd patogenezy, epidemiologii, diagnostyki i strategii terapeutycznych. Insight into Epidemiology (Ed polska). 2024;1(1).
Malfertheiner P, Camargo MC, El-Omar E, et al. Helicobacter pylori infection. Nature Reviews Disease Primers. 2023;9(1):1-24.
Lee YC, Dore MP, Graham DY. Diagnosis and Treatment of Helicobacter pylori Infection. Annual Review of Medicine. 2022;73(1):183-195.
Ansari S, Yamaoka Y. Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity. Toxins. 2019; 11(11):677.
Gonciarz M, Pruszowski J, Krzyżowska K. Zasady diagnostyki i leczenia zakażenia bakterią Helicobacter pylori. Lekarz POZ. 2017;3(3):161-168.
Bordin DS, Voynovan IN, Andreev DN, Maev IV. Current Helicobacter pylori Diagnostics. Diagnostics. 2021; 11(8):1458.
Omar M, Razi Abu-Salah, Reem Agbareia, et al. A comparative systematic review and meta-analysis on the diagnostic accuracy of non-invasive tests for Helicobacter pylori detection in elderly patients. Frontiers in Medicine. 2023;10.
Huang Q, Jia X, Chu Y, Zhang X, Ye H. Helicobacter pylori Infection in Geriatric Patients: Current Situation and Treatment Regimens. Frontiers in Medicine. 2021;8:713908.
Liao EC, Yu CH, Lai JH, et al. A pilot study of non-invasive diagnostic tools to detect Helicobacter pylori infection and peptic ulcer disease. Scientific Reports. 2023;13(1):22800.
Sabbagh P, Mohammadnia-Afrouzi M, Javanian M, et al. Diagnostic methods for Helicobacter pylori infection: ideals, options, and limitations. European Journal of Clinical Microbiology & Infectious Diseases. 2018;38(1):55-66.
Pichon M, Pichard B, Barrioz T, et al. Diagnostic Accuracy of a Noninvasive Test for Detection of Helicobacter pylori and Resistance to Clarithromycin in Stool by the Amplidiag H. pylori+ClariR Real-Time PCR Assay. Onderdonk AB, ed. Journal of Clinical Microbiology. 2020;58(4).
Ferwana M, Abdulmajeed I, Alhajiahmed A, et al. Accuracy of urea breath test in Helicobacter pylori infection: meta-analysis. World J Gastroenterol. 2015;21(4):1305-1314.
Kouitcheu Mabeku LB, Bello Epesse M, Fotsing S, Kamgang R, Tchidjo M. Stool Antigen Testing, a Reliable Noninvasive Method of Assessment of Helicobacter pylori Infection Among Patients with Gastro-duodenal Disorders in Cameroon. Digestive Diseases and Sciences. 2020;66(2):511-520.
Godbole G, Mégraud F, Bessède E. Review: Diagnosis of Helicobacter pylori infection. Helicobacter. 2020;25:e12735.
Tanaka S, Goto A, Yamagishi K, et al. Long-term Response of Helicobacter pylori Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study. J Epidemiol. 2023;33(1):1-7.
Bartnik W, Celińska-Cedro D, Dzieniszewski J, Łaszewicz W, Mach T, Przytulski K, Skrzydło-Radomańska B. Wytyczne Polskiego Towarzystwa Gastroenterologii dotyczące diagnostyki i leczenia zakażenia Helicobacter pylori. Gastroenterol Klin Postępy Stand. 2014;6(2):41-49.
Urgessa NA, Geethakumari P, Kampa P, et al. A Comparison Between Histology and Rapid Urease Test in the Diagnosis of Helicobacter Pylori in Gastric Biopsies: A Systematic Review. Cureus. 2023;15(5):e39360.
Pohl D, Keller PM, Bordier V, Wagner K. Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing. World J Gastroenterol. 2019;25(32):4629-4660.
Thasneem H, Sidhic K. Rapid urease test in the diagnosis of pylori infection. Kerala Surgical Journal. 2021;27(2):153.
Lopes AI, Vale FF, Oleastro M. Helicobacter pylori infection-recent developments in diagnosis. World J Gastroenterol. 2014;20(28):9299.
Lee HS. Histopathologic Diagnosis of H. pylori Infection and Associated Gastric Diseases. Helicobacter pylori. Published online 2016:119-127..
Skrebinska S, Megraud F, Daugule I, Santare D, Isajevs S, Liepniece-Karele I, Bogdanova I, Rudzite D, Vangravs R, Kikuste I, et al. Who Could Be Blamed in the Case of Discrepant Histology and Serology Results for Helicobacter pylori Detection? Diagnostics. 2022; 12(1):133.
Lee JY, Kim N. Diagnosis of Helicobacter pylori by invasive test: histology. Ann Transl Med. 2015;3(1):10.
Robinson K, Atherton JC. The Spectrum of Helicobacter-Mediated Diseases. Annual Review of Pathology: Mechanisms of Disease. 2021;16(1):123-144.
Zamani M, Shaghayegh Alizadeh‐Tabari, Amir Hossein Hasanpour, Eusebi LH, Ford AC. Systematic review with meta‐analysis: association of Helicobacter pylori infection with gastro‐oesophageal reflux and its complications. Alimentary Pharmacology & Therapeutics. 2021;54(8):988-998.
Pellicano R, Ianiro G, Fagoonee S, Settanni CR, Gasbarrini A. Review: Extragastric diseases and Helicobacter pylori. Helicobacter. 2020;25(S1).
Bereda G. Definition, Causes, Pathophysiology, and Management of Hypothyroidism. Mathews Journal of Pharmaceutical Science. 2023;7(1):1-5.
Laucirica I, Garcia Iglesias P, Calvet X. Peptic ulcer. Medicina Clínica (English Edition). 2023;161(6):260-266.
Gupta A, Shetty S, Srinivas Mutalik, et al. Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation. Heliyon. 2023;9(10).
Banks M, Graham D, Jansen M, et al. British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. Gut. 2019;68(9):1545-1575.
Szczeklik A, eds. Interna Szczeklika. Mały podręcznik. Medycyna Praktyczna; 2023:644-645.
Piscione M, Mazzone M, Di Marcantonio MC, Muraro R, Mincione G. Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship. Frontiers in Microbiology. 2021;12.
Valenzuela MA, Canales J, Corvalan AH, Quest AF. Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. World J Gastroenterol. 2015;21(45):12742-12756.
Vlăduţ C, Ciocîrlan M, Costache R, et al. Is mucosa‑associated lymphoid tissue lymphoma an infectious disease? Role of Helicobacter pylori and eradication antibiotic therapy (Review). Experimental and Therapeutic Medicine. 2020;20(4).
Salar A. Gastric MALT lymphoma and Helicobacter pylori. Medicina Clínica (English Edition). 2019;152(2):65-71.
Feldman M, Lawrence JB. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:473-477.
Thung I, Aramin H, Vavinskaya V, et al. Review article: the global emergence ofHelicobacter pyloriantibiotic resistance. Alimentary Pharmacology & Therapeutics. 2015;43(4):514-533.
Van Boeckel TP, Gandra S, Ashok A, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742-750.
Bujanda L, Nyssen OP, Vaira D, et al. Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013–2020: Results of the European Registry on H. pylori Management (Hp-EuReg). Antibiotics. 2021;10(9):1058.
Kallirroi Kotilea, Iliadis E, Nguyen J, et al. Antibiotic resistance, heteroresistance, and eradication success of Helicobacter pylori infection in children. Helicobacter. 2023;28(5).
Tshibangu-Kabamba E, Yamaoka Y. Helicobacter pylori infection and antibiotic resistance — from biology to clinical implications. Nature Reviews Gastroenterology & Hepatology. 2021;18(9):613-629.
Hu Y, Zhang M, Lu B, Dai J. Helicobacter pylori and Antibiotic Resistance, A Continuing and Intractable Problem. Helicobacter. 2016;21(5):349-363
Chen JN, Li P, Huang Y, Guo Y, Ding Z, Lu H. Primary Antibiotic Resistance of Helicobacter pylori in Different Regions of China: A Systematic Review and Meta-Analysis. Pathogens. 2022;11(7):786-786.
Szczeklik A, eds. Interna Szczeklika. Mały podręcznik. Medycyna Praktyczna; 2023:639-641
Ierardi E, Losurdo G, Mileti A, et al. The Puzzle of Coccoid Forms of Helicobacter pylori: Beyond Basic Science. Antibiotics. 2020;9(6):293.
Duan M, Liu J, Zuo X. Dual therapy for Helicobacter pylori infection. Chinese Medical Journal. 2023;136(1):13-23.
Yu L, Luo L, Long X, et al. High-dose PPI-amoxicillin dual therapy with or without bismuth for first-line Helicobacter pylori therapy: a randomized trial. Helicobacter. 2019; 24(4):e12596.
Gao C, Zhang D, Zhang T, et al. PPI‐amoxicillin dual therapy for Helicobacter pylori infection: An update based on a systematic review and meta‐analysis. Helicobacter. 2020;25(4).
Fedorowicz SA, Nowak P, Kowalski M, et al. Helicobacter pylori–dotychczasowa terapia i leczenie współczesne. Pielęgniarstwo. 2020;49
Tariq H, Patel H, Kamal MU, et al. Reevaluation of the efficacy of first-line regimen for Helicobacter pylori. Clin Exp Gastroenterol. 2020;13:25-33.
Li B, Lan X, Wang L, et al. Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: a meta-analysis. Microb Pathog. 2020;142:104075.
Nyssen OP, McNicholl AG, Gisbert JP. Meta‐analysis of three‐in‐one single capsule bismuth‐containing quadruple therapy for the eradication ofHelicobacter pylori. Helicobacter. 2019;24(2):e12570.
Dore MP, Lu H, Graham DY. Role of bismuth in improvingHelicobacter pylorieradication with triple therapy. Gut. 2016;65(5):870-878.
Duan M, Kong Q, Wang H, Li Y. Optimal Duration of Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta‐Analysis. Helicobacter. 2024;29(5).
Rocco Maurizio Zagari, Dajti E, Cominardi A, et al. Standard Bismuth Quadruple Therapy versus Concomitant Therapy for the First-Line Treatment of Helicobacter pylori Infection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Medicine. 2023;12(9):3258-3258.
Patricio Medel‐Jara, Diego Reyes Placencia, Fuentes‐López E, et al. Quadruple therapies show a higher eradication rate compared to standard triple therapy for Helicobacter pylori infection within the LEGACy consortium. A multicenter observational study in European and Latin American countries. United European Gastroenterology Journal. 2024;12(9).
Song ZQ, Zhou LY. Hybrid, sequential and concomitant therapies forHelicobacter pylorieradication: A systematic review and meta-analysis. World Journal of Gastroenterology. 2016;22(19):4766.
Mestrovic A, Perkovic N, Bozic J, et al. Randomised clinical trial comparing concomitant and hybrid therapy for eradication of Helicobacter pylori infection. Gluud LL, ed. PLOS ONE.
Wang Y, Zhao R, Wang B, et al. Sequential versus concomitant therapy for treatment of Helicobacter pylori infection: an updated systematic review and meta-analysis. Eur J Clin Pharmacol. 2018;74:1-13.
Farhoud NS, Ibrahim OM, Ezzat SE. Efficacy and Cost-effectiveness Comparison of 10-Day, 14-Day Sequential Versus 14-Day Triple Therapies for Treating Helicobacter pylori Infection in Egyptian Patients. J Clin Gastroenterol. 2020;54(9):806-812.
Nyssen OP, Espada M, Gisbert JP. Empirical vs. Susceptibility-Guided Treatment of Helicobacter pylori Infection: A Systematic Review and Meta-Analysis. Frontiers in Microbiology. 2022;13.
Gingold‐Belfer R, Niv Y, Hemda Schmilovitz‐Weiss, Levi Z, Boltin D. Susceptibility‐guided versus empirical treatment for Helicobacter pylori infection: A systematic review and meta‐analysis. Journal of Gastroenterology and Hepatology. 2021;36(10):2649-2658.
Malfertheiner P, Megraud F, O'Morain CA, Gisbert JP, Kuipers EJ, Axon AT, Bazzoli F, Gasbarrini A, Atherton J, Graham DY, Hunt R, Moayyedi P, Rokkas T, Rugge M, Selgrad M, Suerbaum S, Sugano K, El-Omar EM European Helicobacter and Microbiota Study Group and Consensus panel. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66:6–30.
McNicholl AG, Linares PM, Nyssen OP, Calvet X, Gisbert JP. Meta-analysis: esomeprazole or rabeprazole vs. first-generation pump inhibitors in the treatment of Helicobacter pylori infection. Alimentary Pharmacology & Therapeutics. 2012;36(5):414-425.
György Miklós Buzás, Péter Birinyi. Newer, Older, and Alternative Agents for the Eradication of Helicobacter pylori Infection: A Narrative Review. Antibiotics. 2023;12(6):946-946.
Shinozaki S, Kobayashi Y, Osawa H, et al. Effectiveness and Safety of Vonoprazan versus Proton Pump Inhibitors for Second-Line Helicobacter pylori Eradication Therapy: Systematic Review and Meta-Analysis. Digestion. 2021;102(3):319-325.
Dong SQ, Singh TP, Wei X, Yao H, Wang HL. Review: A Japanese population-based meta-analysis of vonoprazan versus PPI forHelicobacter pylorieradication therapy: Is superiority an illusion? Helicobacter. 2017;22(6):e12438.
Shinozaki S, Kobayashi Y, Osawa H, et al. Effectiveness and Safety of Vonoprazan versus Proton Pump Inhibitors for Second-Line Helicobacter pylori Eradication Therapy: Systematic Review and Meta-Analysis. Digestion. 2021;102(3):319-325.
Zhang M, Pang M, Zhang M. Efficacy and safety of potassium-competitive acid blockers versus proton pump inhibitors as Helicobacter pylori eradication therapy: a meta-analysis of randomized clinical trials. Clinics. 2022;77:100058.
Chen X, Shan T, Ren B, et al. Dimethylaminododecyl Methacrylate-Incorporated Dental Materials Could Be the First Line of Defense against Helicobacter pylori. Int J Mol Sci. 2023;24(17):13644.
Escobedo-Hinojosa WI, Del Carpio JD, Palacios-Espinosa JF, Romero I. Contribution to the ethnopharmacological and anti-Helicobacter pylori knowledge of Cyrtocarpa procera Kunth (Anacardiaceae). J Ethnopharmacol. 2012;
Opublikowane
Licencja

Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Użycie niekomercyjne – Bez utworów zależnych 4.0 Międzynarodowe.