Optogenetyka w zrozumieniu PTSD, czyli jak rzucić światło na patomechanizm traumy?

World Health Organization. International Classification of Diseases, 11th Revision (ICD-11). Post-Traumatic Stress Disorder (6B40). World Health Organization; 2019. Accessed April 11, 2025. https://icd.who.int

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed, text rev. Post-Traumatic Stress Disorder (309.81). American Psychiatric Association Publishing; 2022.

Smith NDL, Cottler LB. The Epidemiology of Post-Traumatic Stress Disorder and Alcohol Use Disorder. Alcohol Res. 2018;39(2):113-120. PMID: 31198651; PMCID: PMC6561398.

Yehuda R, Hoge CW, McFarlane AC, et al. Post-traumatic stress disorder. Nat Rev Dis Primers. 2015;1:15057. Published 2015 Oct 8. doi:10.1038/nrdp.2015.57

Bilewicz M, Babińska M, Gromova A. High rates of probable PTSD among Ukrainian war refugees: the role of intolerance of uncertainty, loss of control and subsequent discrimination. Eur J Psychotraumatol. 2024;15(1):2394296. doi:10.1080/20008066.2024.2394296

Schrader C, Ross A. A Review of PTSD and Current Treatment Strategies. Mo Med. 2021;118(6):546-551.

Fitzgerald JM, DiGangi JA, Phan KL. Functional Neuroanatomy of Emotion and Its Regulation in PTSD. Harv Rev Psychiatry. 2018;26(3):116-128. doi:10.1097/HRP.0000000000000185

Garfinkel SN, Liberzon I. Neurobiology of PTSD: A review of neuroimaging findings. Psychiatr Ann. 2009;39(6):370–372, 376–381. doi:10.3928/00485713-20090527-01

Ressler KJ, Berretta S, Bolshakov VY, et al. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022;18(5):273-288. doi:10.1038/s41582-022-00635-8

Alexandra Kredlow M, Fenster RJ, Laurent ES, Ressler KJ, Phelps EA. Prefrontal cortex, amygdala, and threat processing: implications for PTSD. Neuropsychopharmacology. 2022;47(1):247-259. doi:10.1038/s41386-021-01155-7

Fakhoury M. Optogenetics: A revolutionary approach for the study of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2021;106:110094. doi:10.1016/j.pnpbp.2020.110094

Nature Methods. Method of the Year 2010. Nat Methods. 2011;8(1):1. doi:10.1038/nmeth.f.321

Shirai F, Hayashi-Takagi A. Optogenetics: Applications in psychiatric research. Psychiatry Clin Neurosci. 2017;71(6):363-372. doi:10.1111/pcn.12516

Zhang F, Gradinaru V, Adamantidis AR, et al. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc. 2010;5(3):439-456. doi:10.1038/nprot.2009.226

Kim CK, Adhikari A, Deisseroth K. Integration of optogenetics with complementary methodologies in systems neuroscience. Nat Rev Neurosci. 2017;18(4):222-235. doi:10.1038/nrn.2017.15

Fenno L, Yizhar O, Deisseroth K. The development and application of optogenetics. Annu Rev Neurosci. 2011;34:389-412. doi:10.1146/annurev-neuro-061010-113817

Wu M, Yang Y, Zhang J, Efimov AI, Vazquez-Guardado A, Li X, Zhang K, Wang Y, Gu J, Zeng L, Liu J, Riahi M, Yoon H, Kim M, Zhang H, Lee M, Kang J, Ting K, Cheng S, Zhang W, Banks A, Good CH, Cox JM, Pinto L, Huang Y, Kozorovitskiy Y, Rogers JA. Patterned wireless transcranial optogenetics generates artificial perception. bioRxiv [Preprint]. 2024 Sep 20:2024.09.20.613966. doi: 10.1101/2024.09.20.613966. PMID: 39345413; PMCID: PMC11429977.

Chen R, Gore F, Nguyen QA, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K. Deep brain optogenetics without intracranial surgery. Nat Biotechnol. 2021 Feb;39(2):161-164. doi: 10.1038/s41587-020-0679-9. Epub 2020 Oct 5. PMID: 33020604; PMCID: PMC7878426.

Chen R, Gore F, Nguyen QA, Ramakrishnan C, Patel S, Kim SH, Raffiee M, Kim YS, Hsueh B, Krook-Magnusson E, Soltesz I, Deisseroth K. Deep brain optogenetics without intracranial surgery. Nat Biotechnol. 2021 Feb;39(2):161-164. doi: 10.1038/s41587-020-0679-9. Epub 2020 Oct 5. PMID: 33020604; PMCID: PMC7878426.

Emiliani V, Cohen AE, Deisseroth K, Häusser M. All-Optical Interrogation of Neural Circuits. J Neurosci. 2015 Oct 14;35(41):13917-26. doi: 10.1523/JNEUROSCI.2916 15.2015. PMID: 26468193; PMCID: PMC4604230.

Lafferty CK, Christinck TD, Britt JP. All-optical approaches to studying psychiatric disease. Methods. 2022;203:46-55. doi:10.1016/j.ymeth.2021.07.007

Fernandez-Ruiz A, Oliva A, Chang H. High-resolution optogenetics in space and time. Trends Neurosci. 2022;45(11):854-864. doi:10.1016/j.tins.2022.09.002

Kanta V, Pare D, Headley DB. Closed-loop control of gamma oscillations in the amygdala demonstrates their role in spatial memory consolidation. Nat Commun. 2019;10(1):3970. Published 2019 Sep 3. doi:10.1038/s41467-019-11938-8

Steinberg EE, Christoffel DJ, Deisseroth K, Malenka RC. Illuminating circuitry relevant to psychiatric disorders with optogenetics. Curr Opin Neurobiol. 2015;30:9 16. doi:10.1016/j.conb.2014.08.004

Johansen JP, Hamanaka H, Monfils MH, et al. Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc Natl Acad Sci U S A. 2010;107(28):12692-12697. doi:10.1073/pnas.1002418107

Daviu N, Bruchas MR, Moghaddam B, Sandi C, Beyeler A. Neurobiological links between stress and anxiety. Neurobiol Stress. 2019;11:100191. Published 2019 Aug 13. doi:10.1016/j.ynstr.2019.100191

Tye KM, Prakash R, Kim SY, et al. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 2011;471(7338):358-362. doi:10.1038/nature09820

Namburi P, Beyeler A, Yorozu S, et al. A circuit mechanism for differentiating positive and negative associations. Nature. 2015;520(7549):675-678. doi:10.1038/nature14366

Ramirez S, Liu X, Lin PA, et al. Creating a false memory in the hippocampus. Science. 2013;341(6144):387-391. doi:10.1126/science.1239073

Al Abed AS, Ducourneau EG, Bouarab C, Sellami A, Marighetto A, Desmedt A. Preventing and treating PTSD-like memory by trauma contextualization. Nat Commun. 2020;11(1):4220. Published 2020 Aug 24. doi:10.1038/s41467-020-18002-w

Canto-de-Souza L, Demetrovich PG, Plas S, et al. Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress. Front Behav Neurosci. 2021;15:780326. Published 2021 Dec 20. doi:10.3389/fnbeh.2021.780326

Smiley CE, McGonigal JT, Nimchuk KE, Gass JT. Optogenetic manipulation of the prelimbic cortex during fear memory reconsolidation alters fear extinction in a preclinical model of comorbid PTSD/AUD. Psychopharmacology (Berl). 2021;238(11):3193-3206. doi:10.1007/s00213-021-05935-3

Sakai D, Tomita H, Maeda A. Optogenetic Therapy for Visual Restoration. Int J Mol Sci. 2022;23(23):15041. Published 2022 Nov 30. doi:10.3390/ijms232315041

Faltus T, Freise J, Fluck C, Zillmann H. Ethics and regulation of neuronal optogenetics in the European Union. Pflugers Arch. 2023;475(12):1505-1517. doi:10.1007/s00424-023-02888-8