Foslewodopa/foskarbidopa - zastępca “złotego standardu” w leczeniu choroby Parkinsona
Keywords:
apomorfina, choroba Parkinsona, foslewodopa/foskarbidopa, lewodopaSynopsis
Choroba Parkinsona to zwyrodnienie struktur mózgu, którego istotą jest zanik komórek dopaminergicznych. Złoty standard leczenia stanowiło do tej pory podawanie lewodopy z karbidopą (inhibitorem dekarboksylazy aromatycznych aminokwasów), jednak poprzez szybki metabolizm substancji, terapia wymagała częstego podawania leków i prowadziła do fluktuacji skuteczności oraz występowania działań niepożądanych.
Foslewodopa z foskarbidopą to innowacyjne proleki stosowane w leczeniu choroby Parkinsona, opracowane w celu poprawy biodostępności lewodopy i zminimalizowania efektów ubocznych związanych z jej stosowaniem. Zapewniają stabilne uwalnianie dopaminy, co prowadzi do bardziej przewidywalnego działania. Badania kliniczne wykazały, że ten schemat leczenia pozwala na dłuższe utrzymanie odpowiedniego poziomu dopaminy, zmniejszając wahania nastroju oraz objawy motoryczne. Celem pracy była analiza bezpieczeństwa oraz porównanie nowej terapii folewodopą/foskarbidopą z dawnymi metodami leczenia choroby Parkinsona.
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