Problem zwłóknienia wątroby u pacjentów pediatrycznych po transplantacji – perspektywa przeszczepu mikrobiomu kałowego.

Natalia Zawronek; Barbara Sławińska; Wiktoria Sokołowska; Karolina Kruk; Maja Kruplewicz; Wojciech Jaworski

Problem zwłóknienia wątroby u pacjentów pediatrycznych po transplantacji – perspektywa przeszczepu mikrobiomu kałowego.

Autorzy

Natalia Zawronek - 1. Studenckie Koło Naukowe im. Zbigniewa Religii przy Katedrze Biofizyki w Zabrzu, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach; Barbara Sławińska - Studenckie Koło Naukowe im. Zbigniewa Religii przy Katedrze Biofizyki w Zabrzu, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach; Wiktoria Sokołowska - Studenckie Koło Naukowe im. Zbigniewa Religii przy Katedrze Biofizyki w Zabrzu, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach; Karolina Kruk - Studenckie Koło Naukowe im. Zbigniewa Religii przy Katedrze Biofizyki w Zabrzu, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach; Maja Kruplewicz - Studenckie Koło Naukowe im. Zbigniewa Religii przy Katedrze Biofizyki w Zabrzu, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach; Wojciech Jaworski - Studenckie Koło Naukowe im. Zbigniewa Religii przy Katedrze Biofizyki w Zabrzu, Wydział Nauk Medycznych w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach

Słowa kluczowe:

pediatria, przeszczep, wątroba, mikrobiom jelitowy, zwłóknienie

Streszczenie

Istotny postęp ostatnich lat w zakresie transplantacji wątroby u pacjentów pediatrycznych umożliwił zauważalne zwiększenie przeżywalności i powodzenia przeszczepów. Pomimo to, większość dziecięcych biorców jest w perspektywie długoterminowej narażona na postępujące włóknienie transplantatu. Celem niniejszego rozdziału jest przybliżenie tego problemu - etiopatogenezy, czynników ryzyka i aktualnego postępowania. W dalszej części, po przeanalizowaniu literatury dotyczącej przeszczepu mikrobiomu kałowego dostępnej w bazach medycznych PubMed oraz Google Scholar, przedstawiono nadzieje wiązane z tą metodą w aspekcie zapobiegania potransplantacyjnej fibrogenezie wątroby. Na tej podstawie został sformułowany wniosek mówiący o niewykorzystanym potencjale terapeutycznym FMT w procesie włóknienia wątroby po przeszczepie u dzieci i ogromnym zapotrzebowaniu na dalsze badania w zakresie jej bezpieczeństwa i skuteczności dla pacjentów pediatrycznych.

Rozdziały

Problem zwłóknienia wątroby u pacjentów pediatrycznych po transplantacji – perspektywa przeszczepu mikrobiomu kałowego.

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